Proteintech, 55323-1-AP, TNKS1BP1 Polyclonal antibody

Size: 20ul / 150ul The TNKS1BP1 (55323-1-AP) by Proteintech is a Polyclonal antibody targeting TNKS1BP1 in WB, ELISA applications with reactivity to human samples 55323-1-AP targets TNKS1BP1 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HeLa cells, HepG2 cells, L02 cells, MCF-7 cells Recommended dilution Western Blot (WB): WB : 1:500-1:2000 Background Information TNKS1BP1, also known as TAB182, is a member of the poly(ADP-ribose) polymerase (PARP) superfamily. It is an anchor polymerase 1 (Tankyrase1) binding protein with a molecular weight of 182 kDa and is widely distributed throughout the cell, including the cell membrane, cytoplasm, and nucleus. TNKS1BP1 functions in both telomere maintenance and DNA damage response. TNKS1BP1 can compete with TRF1 to bind to the multiple binding sites of tankyrase1, potentially interfering with the transport of tankyrase1 from cytoplasm to nucleus and its localization in telomeres, which affects the stability of telomeres (PMID: 28058814, PMID: 39019859, PMID: 39113018). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: tankyrase 1 binding protein 1, 182kDa Calculated Molecular Weight: 182 kDa Observed Molecular Weight: 182 kDa GenBank Accession Number: NM_033396 Gene Symbol: TNKS1BP1 Gene ID (NCBI): 85456 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q9C0C2 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.