Proteintech, 55326-1-AP, QSER1 Polyclonal antibody

Size: 20ul / 150ul The QSER1 (55326-1-AP) by Proteintech is a Polyclonal antibody targeting QSER1 in IHC, IF/ICC, ELISA applications with reactivity to human samples 55326-1-AP targets QSER1 in IHC, IF/ICC, ELISA applications and shows reactivity with human samples. Tested Applications Positive IHC detected in: human pancreas cancer tissueNote: suggested antigen retrieval withTE buffer pH 9.0;(*) Alternatively, antigen retrieval may be performed withcitrate buffer pH 6.0 Positive IF/ICC detected in: HeLa cells Recommended dilution Immunohistochemistry (IHC): IHC : 1:50-1:500 Immunofluorescence (IF)/ICC: IF/ICC : 1:200-1:800 Background Information QSER1, a recently characterized protein, whose activity has been tightly associated with the protection of DNA methylation sites in hESCs. QSER1 is widely up-regulated in multiple cancers, and its up-regulation correlates with poor clinic outcomes (PMID: 36371602). QSER1 depletion leads to NODAL de-repression and associates with increased RNA Polymerase II occupancy at YAP1bound enhancers, pointing to a QSER1 contribution maintaining low transcriptional activity on certain genomic regions (PMID: 33833093, 35210841). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Polyclonal Type: Antibody Immunogen: Peptide Predict reactive species Full Name: glutamine and serine rich 1 Calculated Molecular Weight: 190 kDa GenBank Accession Number: NM_001076786 Gene Symbol: QSER1 Gene ID (NCBI): 79832 Conjugate: Unconjugated Form: Liquid Purification Method: Antigen affinity purification UNIPROT ID: Q2KHR3 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.