Proteintech, 65098-1-Ig, Anti-Mouse LAG-3/CD223 (C9B7W)

Size: 500ug The LAG-3/CD223 (65098-1-Ig) by Proteintech is a Monoclonal antibody targeting LAG-3/CD223 in FC applications with reactivity to mouse samples 65098-1-Ig targets LAG-3/CD223 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: Con-A stimulated mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information Lymphocyte activation gene 3 protein (LAG-3), also known as CD223, is a type I transmembrane protein belonging to the immunoglobulin superfamily (PMID: 1692078). It is a CD4-related molecule that binds MHC class II with high affinity (PMID: 1692078; 9159144). LAG-3 is expressed on activated T and NK cells. Besides, natural CD4(+)CD25(+) Tregs express LAG-3 upon activation (PMID: 15485628). LAG-3 negatively regulates T-cell function and homeostasis, and contributes to the suppressor activity of Tregs (PMID: 14644131; 15485628). Specification Tested Reactivity: mouse Host / Isotype: Rat / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: Murine CD223-Ig fusion protein Predict reactive species Full Name: lymphocyte-activation gene 3 GenBank Accession Number: BC120591 Gene Symbol: CD223 Gene ID (NCBI): 16768 RRID: AB_2918400 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: Q61790 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.