Proteintech, 65118-1-Ig, Anti-Human CD86 (IT2.2)

Size: 100ug / 500ug The CD86 (65118-1-Ig) by Proteintech is a Monoclonal antibody targeting CD86 in FC applications with reactivity to Human samples 65118-1-Ig targets CD86 in FC applications and shows reactivity with Human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information CD86 (also known as B7-2) is a costimulatory molecule belonging to the immunoglobulin superfamily. Primarily expressed on antigen-presenting cells (APCs), including B cells, dendritic cells, and macrophages, CD86 is the ligand for two proteins at the cell surface of T cells, CD28 antigen and CTLA-4. Binding of CD86 with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of CD86 with CTLA-4 negatively regulates T-cell activation and diminishes the immune response. (PMID: 7513726; 1847722; 11029388; 27591335) Specification Tested Reactivity: Human Host / Isotype: Mouse / IgG2b, kappa Class: Monoclonal Type: Antibody Immunogen: N/A Predict reactive species Full Name: CD86 molecule Calculated Molecular Weight: 329 aa, 38 kDa GenBank Accession Number: BC040261 Gene Symbol: CD86 Gene ID (NCBI): 942 ENSEMBL Gene ID: ENSG00000114013 RRID: AB_3084900 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P42081 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.