Proteintech, 65138-1-Ig, Anti-Mouse NK1.1 (CD161) (PK136)

Size: 500ug The NK1 65138-1-Ig targets NK1.1 (CD161) in FC applications and shows reactivity with Mouse samples. Tested Applications Positive FC detected in: C57BL/6 mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.5 ug per 10^6 cells in 100 μl suspension Background Information NK1.1 (CD161), also known as KLRB1 or NKR-P1A, is a type II transmembrane C-type lectin-like receptor and is expressed on the cell membrane as disulfide-linked homodimer (PMID: 8077657). It is expressed by the majority of NK cells and subsets of peripheral T cells, including both CD4+ and CD8+ T cells, and is expressed preferentially on adult T cells with a "memory" antigenic phenotype (PMID: 8077657; 22566826). Expression of CD161 correlates with the cytotoxic function of CD16+ NK cells, and ligation of CD161 with its ligand LLT1 inhibits NK cell cytotoxicity and cytokine secretion (PMID: 29686665). Specification Tested Reactivity: Mouse Host / Isotype: Mouse / IgG2a, kappa Class: Monoclonal Type: Antibody Immunogen: NK-1+ cells from mouse spleen and bone marrow Predict reactive species Full Name: killer cell lectin-like receptor subfamily B member 1A GenBank Accession Number: BC120707 Gene Symbol: NK1.1 Gene ID (NCBI): 17057 RRID: AB_2918425 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: P27811 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.