Proteintech, 65173-1-Ig, Anti-Human CD41 (HIP8)

Size: 100ug / 500ug The CD41 (65173-1-Ig) by Proteintech is a Monoclonal antibody targeting CD41 in FC applications with reactivity to human, non-human primates samples 65173-1-Ig targets CD41 in FC applications and shows reactivity with human, non-human primates samples. Tested Applications Positive FC detected in: human peripheral blood Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information The integrins are a superfamily of cell adhesion receptors that bind to extracellular matrix ligands, cell-surface ligands, and soluble ligands (PMID: 17543136). They are transmembrane αβ heterodimers and at least 24 distinct integrin heterodimers are formed by the combination of 18 α and eight β known subunits (PMID: 17543136; 20029421). In addition to mediating cell adhesion, integrins also play important roles in modulating signal transduction pathways that control cellular responses including migration, proliferation, differentiation, and apoptosis (PMID: 19118207). Integrin alpha-IIb (ITGA2B, CD41) is expressed on platelets, megakaryocytes and some hematopoietic progenitor cells (PMID: 11934866). This protein undergoes post-translational cleavage to yield disulfide linked light beta (25 kDa) and heavy alpha (125 kDa) chains, which join with integrin beta3 (CD61) to form a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. CD41/CD61 is crucial for platelet aggregation through binding of soluble fibrinogen. The HIP8 clone antibody specifically binds to the alpha chain of CD41. Specification Tested Reactivity: human, non-human primates Host / Isotype: Mouse / IgG1, kappa Class: Monoclonal Type: Antibody Immunogen: N/A Predict reactive species Full Name: integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) GenBank Accession Number: BC117443 Gene Symbol: CD41 Gene ID (NCBI): 3674 RRID: AB_2881482 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: P08514 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.