Proteintech, 65270-1-Ig, Anti-Human CD244 (2B4.69)

Size: 100ug / 500ug The CD244 (65270-1-Ig) by Proteintech is a Monoclonal antibody targeting CD244 in FC applications with reactivity to Human samples 65270-1-Ig targets CD244 in FC applications and shows reactivity with Human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.2 ug per 10^6 cells in 100 μl suspension Background Information CD244, also known as SLAMF4 or 2B4, is a type I transmembrane glycoprotein belonging to the signaling lymphocyte activation molecule (SLAM) family. It consists of an extracellular segment with two immunoglobulin (Ig)-like domains, a transmembrane region, and a cytoplasmic domain containing tyrosine-based motifs (PMID: 9841922; 30546369). CD244 is present on natural killer (NK) cells, γδ T cells, a subset of CD8+ T cells, monocytes, basophils, dendritic cells, and myeloid-derived suppressor cells (MDSCs) (PMID: 30546369). It binds to CD48 with high affinity and transmits stimulatory or inhibitory signals that regulate immune function (PMID: 9841922; 18523281). Specification Tested Reactivity: Human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: N/A Predict reactive species Full Name: CD244 molecule, natural killer cell receptor 2B4 GenBank Accession Number: BC028073 Gene Symbol: CD244 Gene ID (NCBI): 51744 RRID: AB_3084914 Conjugate: Unconjugated Form: Liquid Purification Method: Affinity purification UNIPROT ID: Q9BZW8 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: 2-8°C.