Proteintech, 65283-1-Ig, Anti-Human M-CSF (3G12E6)

Size: 100ug The M-CSF (65283-1-Ig) by Proteintech is a Monoclonal antibody targeting M-CSF in FC (Intra) applications with reactivity to human samples 65283-1-Ig targets M-CSF in FC (Intra) applications and shows reactivity with human samples. Tested Applications Positive FC (Intra) detected in: LPS, TNF-α and Brefeldin A treated human PBMCs Recommended dilution Flow Cytometry (FC) (INTRA): FC (INTRA) : Background Information M-CSF plays an essential role in the regulation of survival, proliferation and differentiation of hematopoietic precursor cells, especially mononuclear phagocytes. M-CSF promotes the release of proinflammatory chemokines, and thereby plays an important role in innate immunity and in inflammatory processes. It also plays an important role in the regulation of osteoclast proliferation and differentiation, the regulation of bone resorption, and is required for normal bone development. On the cellular level, M-CSF promotes reorganization of the actin cytoskeleton, regulates formation of membrane ruffles, cell adhesion and cell migration and plays a role in lipoprotein clearance (PMID: 29734839; 29679908; 28202039) Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: colony stimulating factor 1 (macrophage) Calculated Molecular Weight: 60 kDa GenBank Accession Number: BC021117 Gene Symbol: M-CSF Gene ID (NCBI): 1435 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: P09603 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Avoid exposure to light. Stable for one year after shipment.