Proteintech, 65588-1-MR, Anti-Human CD42b (AK2) Mouse IgG2a Recombinant Antibody

Size: 100ug The CD42b (65588-1-MR) by Proteintech is a Recombinant antibody targeting CD42b in FC applications with reactivity to Human samples 65588-1-MR targets CD42b in FC applications and shows reactivity with Human samples. Tested Applications Positive FC detected in: human peripheral blood platelets Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD42b, also known as platelet glycoprotein Ib alpha chain (GPIb alpha), is a type I transmembrane glycoprotein of 135-145 kDa (PMID: 2656709). It is expressed on platelets and megakaryocytes. CD42b and CD42c (GPIb beta) are linked by a disulphide bond to form GPIb (PMID: 7660135). GPIb forms a noncovalent complex with CD42a (GPIX) and CD42d (GPV) and acts as a receptor for von Willebrand factor (vWF) and thrombin (PMID: 7660135; 3759960). The GPIb-V-IX complex mediates vWF-dependent platelet adhesion to blood vessels. Defects in the expression of CD42b result in Bernard-Soulier syndromes and platelet-type von Willebrand disease (PMID: 9371310). Specification Tested Reactivity: Human Host / Isotype: Mouse / IgG2a Class: Recombinant Type: Antibody Immunogen: Human platelets Predict reactive species Full Name: glycoprotein Ib (platelet), alpha polypeptide Calculated Molecular Weight: 626 aa, 69 kDa GenBank Accession Number: BC027955 Gene Symbol: CD42b Gene ID (NCBI): 2811 ENSEMBL Gene ID: ENSG00000185245 RRID: AB_3670338 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P07359 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2-8°C. Stable for one year after shipment.