Proteintech, 66704-1-Ig, IFNGR1/CD119 Monoclonal antibody

Size: 20ul / 150ul The IFNGR1/CD119 (66704-1-Ig) by Proteintech is a Monoclonal antibody targeting IFNGR1/CD119 in WB, ELISA applications with reactivity to human samples 66704-1-Ig targets IFNGR1/CD119 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: HeLa cells, HEK-293 cells, T-47D cells, Jurkat cells Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information Interferon-gamma (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113) Specification Tested Reactivity: human Host / Isotype: Mouse / IgG2a Class: Monoclonal Type: Antibody Immunogen: CatNo: Ag27085 Product name: Recombinant human IFNGR1 protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 189-489 aa of BC005333 Sequence: TQKEDDCDEIQCQLAIPVSSLNSQYCVSAEGVLHVWGVTTEKSKEVCITIFNSSIKGSLWIPVVAALLLFLVLSLVFICFYIKKINPLKEKSIILPKSLISVVRSATLETKPESKYVSLITSYQPFSLEKEVVCEEPLSPATVPGMHTEDNPGKVEHTEELSSITEVVTTEENIPDVVPGSHLTPIERESSSPLSSNQSEPGSIALNSYHSRNCSESDHSRNGFDTDSSCLESHSSLSDSEFPPNNKGEIKTEGQELITVIKAPTSFGYDKPHVLVDLLVDDSGKESLIGYRPTEDSKEFS Predict reactive species Full Name: interferon gamma receptor 1 Calculated Molecular Weight: 54 kDa Observed Molecular Weight: 90 kDa GenBank Accession Number: BC005333 Gene Symbol: IFNGR1 Gene ID (NCBI): 3459 RRID: AB_2882056 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P15260 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.