Proteintech, 67782-1-Ig, GUCY2C Monoclonal antibody

Size: 20ul / 150ul The GUCY2C (67782-1-Ig) by Proteintech is a Monoclonal antibody targeting GUCY2C in WB, ELISA applications with reactivity to human samples 67782-1-Ig targets GUCY2C in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: Caco-2 cells, HaCaT cells, HeLa cells Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information GUCY2C is also named as GUC2C, STAR(Heat-stable enterotoxin receptor), Guanylyl cyclase C and belongs to the adenylyl cyclase class-4/guanylyl cyclase family. It is a receptor for the E.coli heat-stable enterotoxin and considered to be the true apical membrane receptor for the endogenous ligands uroguanylin and guanylin. GUCY2C is not present in the endocrine pancreas, but is localized exclusively to the ductal system which fully corresponds to the GUCY2C activity detected in the exocrine ductal system, but particularly not in islets of Langerhans. GUCY2C with a molecular mass of 130 kDa is detected in pancreatic and intestinal extracts.(PMID:11431160). The full length protein is 123 kDa and has a signal peptide and nine glycosylation sites. Specification Tested Reactivity: human Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: CatNo: Ag19256 Product name: Recombinant human GUCY2C protein Source: e coli. -derived, PET28a Tag: 6*His Domain: 25-372 aa of BC136544 Sequence: QVSQNCHNGSYEISVLMMGNSAFAEPLKNLEDAVNEGLEIVRGRLQNAGLNVTVNATFMYSDGLIHNSGDCRSSTCEGLDLLRKISNAQRMGCVLIGPSCTYSTFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKTNDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVSYFSHELGFKVVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDIVIILVDLFNDQYLEDNVTAPDYMKNVLVLTLSPGNSLLNSSFSRNLSPTKRDFALAYLNGILLFGHMLKIFLENGENITTPKFAHAFRNLTFEGYDGPVTLDDW Predict reactive species Full Name: guanylate cyclase 2C (heat stable enterotoxin receptor) Calculated Molecular Weight: 1073 aa, 123 kDa Observed Molecular Weight: 130 kDa GenBank Accession Number: BC136544 Gene Symbol: GUCY2C Gene ID (NCBI): 2984 RRID: AB_2918546 Conjugate: Unconjugated Form: Liquid Purification Method: Protein G purification UNIPROT ID: P25092 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.