Proteintech, 69011-1-Ig, NeutraKine® BMP-7 Mouse McAb

Size: 25ug / 100ug The NeutraKine® BMP-7 (69011-1-Ig) by Proteintech is a Monoclonal antibody targeting NeutraKine® BMP-7 in FC (Intra), Neutralization, ELISA applications with reactivity to human, mouse samples 69011-1-Ig targets NeutraKine® BMP-7 in FC (Intra), Neutralization, ELISA applications and shows reactivity with human, mouse samples. Background Information The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site.BMP7, also known as osteogenic protein-1 or OP-1, plays a key role in the transformation of mesenchymal cells into bone and cartilage. BMP7 may be involved in bone homeostasis (PMID: 15621726). It is expressed in the brain, kidneys and bladder. BMP7 is also present in cancers, including breast, prostate, and colon cancers, in which it is implicated in regulating cancer cell proliferation (PMID: 16419056, PMID: 15531927). Overexpression of BMP7 mRNA in colorectal cancer patients was significantly associated with poor prognosis and low overall survival (PMID: 18259822). Recent studies suggest that high-expression level of BMP7 serves as a biomarker for poor prognosis for HCC (PMID: 23179403).This antibody can be used to neutralize the bioactivity of BMP-7. Specification Tested Reactivity: human, mouse Host / Isotype: Mouse / IgG1 Class: Monoclonal Type: Antibody Immunogen: CatNo: Product name: HumanKine® recombinant human BMP-7 protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species Full Name: bone morphogenetic protein 7 Gene Symbol: BMP7 Gene ID (NCBI): 655 RRID: AB_2882929 Conjugate: Unconjugated Form: Lyophilized Powder Purification Method: Protein G purification UNIPROT ID: P18075 Storage Buffer: Sterile PBS, pH 7.4. Endotoxin: <0.1 EU/μg Reconstitution: This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. Stability and Storage: Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products.