Proteintech, 82766-15-RR, IL-22 Recombinant monoclonal antibody

Size: 20ul / 100ul The IL-22 (82766-15-RR) by Proteintech is a Recombinant antibody targeting IL-22 in WB, ELISA applications with reactivity to human samples 82766-15-RR targets IL-22 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: Transfected with Human IL22 CHO cells, Recombinant protein Recommended dilution Western Blot (WB): WB : 1:2000-1:10000 Background Information Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: interleukin 22 Observed Molecular Weight: 20 kDa GenBank Accession Number: BC066263 Gene Symbol: IL-22 Gene ID (NCBI): 50616 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9GZX6 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.