Proteintech, 83691-3-RR, ASGR1 Recombinant monoclonal antibody

Size: 20ul / 100ul The ASGR1 (83691-3-RR) by Proteintech is a Recombinant antibody targeting ASGR1 in WB, IF-P, ELISA applications with reactivity to human, rat samples 83691-3-RR targets ASGR1 in WB, IF-P, ELISA applications and shows reactivity with human, rat samples. Tested Applications Positive WB detected in: HepG2 cells, HuH-7 cells, human liver tissue, rat liver tissue Positive IF-P detected in: rat liver tissue Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Immunofluorescence (IF)-P: IF-P : 1:50-1:500 Background Information Asialoglycoprotein receptor (ASGPR), also known as the hepatic galactose/N-acetylglucosamine (GlcNAc) receptor or Ashwell receptor, is a C-type lectin expressed exclusively in hepatic parenchymal cells. ASGPR consists of two subunits, a major subunit (ASGR1, HL-1) and a minor subunit (ASGR2, HL-2), and specifically recognizes terminal β-linked galactose or GlcNAc on circulating glycoproteins or cells. This receptor plays a critical role in serum glycoprotein homeostasis by mediating the endocytosis and lysosomal degradation of glycoproteins that contain terminal galactose or GlcNAc residues. ASGPR may facilitate hepatic infection by multiple viruses including hepatitis B, and is also a target for liver-specific drug delivery. Specification Tested Reactivity: human, rat Cited Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg0946 Product name: Recombinant Human ASGR1 protein (His Tag) Source: mammalian cells -derived, pHZ-KIsec-C-6*HIS Tag: N-6*His Domain: 62-291 aa of NM_001671.4 Sequence: QNSQLQEELRGLRETFSNFTASTEAQVKGLSTQGGNVGRKMKSLESQLEKQQKDLSEDHSSLLLHVKQFVSDLRSLSCQMAALQGNGSERTCCPVNWVEHERSCYWFSRSGKAWADADNYCRLEDAHLVVVTSWEEQKFVQHHIGPVNTWMGLHDQNGPWKWVDGTDYETGFKNWRPEQPDDWYGHGLGGGEDCAHFTDDGRWNDDVCQRPYRWVCETELDKASQEPPLL Predict reactive species Full Name: asialoglycoprotein receptor 1 Calculated Molecular Weight: 33 kDa Observed Molecular Weight: 42-46 kDa GenBank Accession Number: NM_001671.4 Gene Symbol: ASGR1 Gene ID (NCBI): 432 RRID: AB_3671295 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P07306-1 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.