Proteintech, 84976-1-RR, Phospho-TrkA (Tyr496)/TrkB (Tyr516) Recombinant monoclonal antibody

Size: 20ul / 100ul The Phospho-TrkA (Tyr496)/TrkB (Tyr516) (84976-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-TrkA (Tyr496)/TrkB (Tyr516) in WB, ELISA applications with reactivity to human samples 84976-1-RR targets Phospho-TrkA (Tyr496)/TrkB (Tyr516) in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: pervanadate treated HeLa cells Recommended dilution Western Blot (WB): WB : 1:1000-1:6000 Background Information The tyrosine kinase receptor TrkA (or neurotrophin receptor kinase 1, NTRK1) has been predominately studied for its role during the development of the nervous system. In developing neurons, TrkA activation upon binding of its ligands nerve growth factor (NGF) or neurotrophin-3 (NT-3) results in the stimulation of various tyrosine kinase-induced signaling pathways leading to neuronal outgrowth. (PMID: 32957504) This antibody recognizes the phosphorylation of TrkA at site 496, which is the phosphorylation of the TrkA-I(isoform 2) sequence at site 490. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: neurotrophic tyrosine kinase, receptor, type 1 Observed Molecular Weight: 140 kDa GenBank Accession Number: BC062580 Gene Symbol: NTRK1 Gene ID (NCBI): 4914 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P04629 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.