Proteintech, 85242-1-RR, Phospho-FRS2 (Tyr436) Recombinant monoclonal antibody

Size: 20ul / 100ul The Phospho-FRS2 (Tyr436) (85242-1-RR) by Proteintech is a Recombinant antibody targeting Phospho-FRS2 (Tyr436) in WB, ELISA applications with reactivity to human, mouse samples 85242-1-RR targets Phospho-FRS2 (Tyr436) in WB, ELISA applications and shows reactivity with human, mouse samples. Tested Applications Positive WB detected in: bFGF treated NIH/3T3 cells Recommended dilution Western Blot (WB): WB : 1:1000-1:4000 Background Information Fibroblast growth factor substrate 2 (FRS2), a lipid-anchored docking protein that is phosphorylated upon activation of FGFR, is critical for recruitment of downstream signaling molecules and links the FGFRs to the Ras/Mek/Erk pathway and the PI3-Kinase/Akt pathway. Studies have found that the phosphotyrosine binding domain of FRS-2 directly binds the Trk receptors at the same phosphotyrosine residue that binds the signaling adapter Shc, suggesting a model in which competitive binding between FRS-2 and Shc regulates differentiation versusproliferation. (PMID: 19053057, PMID: 10092678) Specification Tested Reactivity: human, mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: fibroblast growth factor receptor substrate 2 Calculated Molecular Weight: 60 kDa Observed Molecular Weight: 80-85 kDa GenBank Accession Number: BC021562 Gene Symbol: FRS2 Gene ID (NCBI): 10818 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q8WU20 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.