Proteintech, 85751-1-RR, KCC2/SLC12A5-Specific Recombinant monoclonal antibody

Size: 20ul / 100ul The KCC2/SLC12A5-Specific (85751-1-RR) by Proteintech is a Recombinant antibody targeting KCC2/SLC12A5-Specific in WB, ELISA applications with reactivity to human, mouse, pig samples 85751-1-RR targets KCC2/SLC12A5-Specific in WB, ELISA applications and shows reactivity with human, mouse, pig samples. Tested Applications Positive WB detected in: mouse brain tissue, rat brain tissue, mouse cerebellum tissue, rat cerebellum Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information KCC2, encoded by SLC12A5, is a neuron-specific K+-Cl- cotransporter that is essential for Cl- homeostasis and inhibitory synaptic transmission in brain. KCC2 is expressed at high levels in neurons throughout the nervous system. KCC2 deletion caused animal death. Alterations of KCC2 have been linked to neuropathic pain, temporal lobe epilepsy, and other diseases. This antibody can detect 130-150 kDa monomer and ~250 kDa dimer of KKC2 in brain lysate. (PMID: 23401525) Specification Tested Reactivity: human, mouse, pig Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: solute carrier family 12 (potassium-chloride transporter), member 5 Calculated Molecular Weight: 126 kDa Observed Molecular Weight: 130-150 kDa GenBank Accession Number: NM_020708 Gene Symbol: KCC2 Gene ID (NCBI): 57468 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9H2X9 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.