Proteintech, 86148-1-RR, GSDMB Recombinant monoclonal antibody

Size: 20ul / 100ul The GSDMB (86148-1-RR) by Proteintech is a Recombinant antibody targeting GSDMB in WB, ELISA applications with reactivity to human samples 86148-1-RR targets GSDMB in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: A431 cells, MCF-7 cells, COLO 320 cells, PC-3 cells Recommended dilution Western Blot (WB): WB : 1:2000-1:10000 Background Information GSDMB (Gasdermin B) is a member of the gasdermin family of proteins, which are involved in the regulation of pyroptosis, a form of programmed cell death. GSDMB plays a crucial role in immune responses, particularly against viral respiratory infections. It has also been implicated in various inflammatory and autoimmune diseases, as well as in cancer progression. GSDMB is known for its ability to induce pyroptosis by forming pores in cell membranes, leading to the release of inflammatory cytokines such as IL-1β and IL-18. This process is critical for combating infections and modulating immune responses. GSDMB can be activated by granzyme A (GZMA), which is released from natural killer (NK) cells and cytotoxic T lymphocytes (CTLs), leading to inflammatory cell death and influencing the tumor immune microenvironment. GSDMB also interacts with other signaling pathways, such as the ERK pathway, to regulate cell proliferation and death. (PMID: 40452932; 38066523; 36163066) Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: gasdermin B Calculated Molecular Weight: 411 aa, 47 kDa Observed Molecular Weight: 47 kDa GenBank Accession Number: BC025682 Gene Symbol: GSDMB Gene ID (NCBI): 55876 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q8TAX9 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.