Proteintech, 86298-2-RR, IL-13RA2 Recombinant monoclonal antibody

Size: 20ul / 100ul The IL-13RA2 (86298-2-RR) by Proteintech is a Recombinant antibody targeting IL-13RA2 in WB, ELISA applications with reactivity to human samples 86298-2-RR targets IL-13RA2 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: A375 cells, U-87 MG cells, U-251 cells Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information IL-13RA2, also named as IL-13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL-13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL-13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL-13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg2579 Product name: recombinant human IL13RA2,CD213A2 protein Source: mammalian cells -derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 27-343 aa of BC020739 Sequence: DTEIKVNPPQDFEIVDPGYLGYLYLQWQPPLSLDHFKECTVEYELKYRNIGSETWKTIITKNLHYKDGFDLNKGIEAKIHTLLPWQCTNGSEVQSSWAETTYWISPQGIPETKVQDMDCVYYNWQYLLCSWKPGIGVLLDTNYNLFYWYEGLDHALQCVDYIKADGQNIGCRFPYLEASDYKDFYICVNGSSENKPIRSSYFTFQLQNIVKPLPPVYLTFTRESSCEIKLKWSIPLGPIPARCFDYEIEIREDDTTLVTATVENETYTLKTTNETRQLCFVVRSKVNIYCSDDGIWSEWSDKQCWEGEDLSKKTLLR Predict reactive species Full Name: interleukin 13 receptor, alpha 2 Calculated Molecular Weight: 380 aa, 44 kDa Observed Molecular Weight: 60 kDa GenBank Accession Number: BC020739 Gene Symbol: IL13RA2 Gene ID (NCBI): 3598 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q14627 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.