Proteintech, 86531-2-RR, Cytokeratin 40 Recombinant monoclonal antibody

Size: 20ul / 100ul The Cytokeratin 40 (86531-2-RR) by Proteintech is a Recombinant antibody targeting Cytokeratin 40 in WB, ELISA applications with reactivity to human samples 86531-2-RR targets Cytokeratin 40 in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: 5637 cells, MCF-7 cells, HaCaT cells Recommended dilution Western Blot (WB): WB : 1:5000-1:50000 Background Information Keratin 40 (KRT40) is a type I (acidic) keratin protein encoded by the KRT40 gene located on human chromosome 17q21.2. As a member of the intermediate filament (IF) protein superfamily, keratin 40 contributes to the cytoskeletal framework of epithelial cells, forming heteropolymeric filaments that provide mechanical support and structural integrity to tissues such as hair follicles, wool fibers, and certain glandular epithelia. KRT40 is expressed at relatively low levels under normal physiological conditions, but its expression becomes significant in specialized contexts. In hair biology, KRT40 is considered a hub gene involved in hair follicle development, cell cycle regulation, and melanogenesis, with its transcripts localized specifically to the fiber cuticle in species like sheep and yak, indicating a structural role in hair shaft formation. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: keratin 40 Calculated Molecular Weight: 431 aa, 48 kDa Observed Molecular Weight: 48 kDa GenBank Accession Number: BC150191 Gene Symbol: Cytokeratin 40 Gene ID (NCBI): 125115 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q6A162 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.