Proteintech, 87510-1-RR, IL-17F Recombinant monoclonal antibody

Size: 20ul / 100ul The IL-17F (87510-1-RR) by Proteintech is a Recombinant antibody targeting IL-17F in WB, ELISA applications with reactivity to human samples 87510-1-RR targets IL-17F in WB, ELISA applications and shows reactivity with human samples. Tested Applications Positive WB detected in: Transfected with Human IL-17F CHO cells Recommended dilution Western Blot (WB): WB : 1:2000-1:10000 Background Information The interleukin 17 (IL-17) family of cytokines contains 6 structurally related cytokines, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E and IL-17F. IL-17 family plays crucial roles in host defense against microbial organisms and in the development of inflammatory diseases. IL-17A is a pro-inflammatory cytokine that also has the capacity to promote angiogenesis and osteoclastogenesis. IL-17F shares the highest homology with IL-17A and signals via a receptor composed by the IL-17RA and IL-17RC subunits. IL-17A and IL-17F can form IL-17A/A or IL-17F/F homodimers, IL-17A/F heterodimers are also formed. IL-17A and IL-17F, produced by the Th17 CD4(+) T cell lineage, have been linked to a variety of inflammatory and autoimmune conditions. IL-17F levels are elevated in sera and lesional psoriatic skin compared to non-lesional tissue. IL-17F also has been implicated in the development of neutrophilic airway inflammation. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg2823 Product name: recombinant human IL17F protein Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 31-163 aa of NM_052872.3 Sequence: RKIPKVGHTFFQKPESCPPVPGGSMKLDIGIINENQRVSMSRNIESRSTSPWNYTVTWDPNRYPSEVVQAQCRNLGCINAQGKEDISMNSVPIQQETLVVRRKHQGCSVSFQLEKVLVTVGCTCVTPVIHHVQ Predict reactive species Full Name: interleukin 17F Calculated Molecular Weight: 18 kDa Observed Molecular Weight: 18-20 kDa GenBank Accession Number: NM_052872.3 Gene Symbol: IL-17F Gene ID (NCBI): 112744 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q96PD4 Storage Buffer: PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. Storage Conditions: Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20 o C storage. 20ul sizes contain 0.1% BSA.