Proteintech, 98092-1-RR, Anti-Human CD22 Rabbit Recombinant Antibody

Size: 100ug The CD22 (98092-1-RR) by Proteintech is a Recombinant antibody targeting CD22 in FC applications with reactivity to human samples 98092-1-RR targets CD22 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD22, also known as Siglec-2 (sialic acid binding Ig-like lectin 2) or BL-CAM (B-lymphocyte cell adhesion molecule), is a 130-140 kDa, B-cell restricted, type I transmembrane glycoprotein belonging to the immunoglobulin gene superfamily. The expression of CD22 is developmentally regulated. It is expressed at low levels in the cytoplasm of pro-B and pre-B cells and present on the cell surface only at mature stages of B-cell differentiation. Cell surface expression is lost during terminal differentiation into plasma cell and after B-cell activation. CD22 is an inhibitory receptor for B-cell receptor (BCR) signalling, preferentially binds to alpha-2,6-linked sialic acid and mediates B-cell B-cell interactions. It plays a crucial role in activation and differentiation of the B-cell. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: CD22 molecule Calculated Molecular Weight: 847 aa, 95 kDa GenBank Accession Number: BC109306 Gene Symbol: CD22 Gene ID (NCBI): 933 RRID: AB_3672239 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P20273 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.