Proteintech, 98139-1-RR, Anti-Human TRAIL/CD253 Rabbit Recombinant Antibody

Size: 100ug The TRAIL/CD253 (98139-1-RR) by Proteintech is a Recombinant antibody targeting TRAIL/CD253 in FC applications with reactivity to human samples 98139-1-RR targets TRAIL/CD253 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: IFN-alpha treated human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information TRAIL, also known as CD253 or TNFSF10 (tumor necrosis factor superfamily member 10), is a typical death ligand expressed on natural killer cells and cytotoxic T lymphocytes. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. TRAIL induces apoptotic cell death in cancer by binding to its functional death receptors, death receptor (DR) 4 (TNFRSF10A/TRAIL-R1) and DR5 (TNFRSF10B/TRAIL-R2) to activate the extrinsic apoptosis pathway. TRAIL also activates c-Jun N-terminal kinase (MAPK8/JNK) and the transcription factor nuclear factor-κB (NFκB). The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: tumor necrosis factor (ligand) superfamily, member 10 Calculated Molecular Weight: 281 aa, 33 kDa GenBank Accession Number: BC032722 Gene Symbol: TRAIL Gene ID (NCBI): 8743 RRID: AB_3672285 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P50591 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.