Proteintech, 98205-1-RR, Anti-Human DC-SIGNR/CD299 Rabbit Recombinant Antibody

Size: 100ug The DC-SIGNR/CD299 (98205-1-RR) by Proteintech is a Recombinant antibody targeting DC-SIGNR/CD299 in FC applications with reactivity to human samples 98205-1-RR targets DC-SIGNR/CD299 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: Transfected HEK-293T cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Dendritic cell-specific intracellular adhesion molecule-3-grabbing non-integrin (DC-SIGN/CD209) and DC-SIGN related (DC-SIGNR/CD299/L-SIGN/CD209L/CLEC4M) are trans-membrane C-type lectins that are calcium-dependent carbohydrate-binding proteins, which can act as cell-adhesion and pathogen-recognition receptors (PMID: 18458800). DC-SIGN and DC-SIGNR share 77% amino acid identity (PMID: 10975799; 11226297). DC-SIGN is expressed on subsets of dendritic cells and macrophages while DC-SIGNR is restricted to endothelial cells of the liver, lymph nodes and placenta (PMID: 17509452). DC-SIGNR servers as a receptor for ICAM-3. It recognizes a wide range of evolutionarily divergent pathogens. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant Protein Predict reactive species Full Name: C-type lectin domain family 4, member M Calculated Molecular Weight: 45 kDa GenBank Accession Number: BC038851 Gene Symbol: DC-SIGNR/CD299 Gene ID (NCBI): 10332 RRID: AB_3672336 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q9H2X3 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.