Proteintech, 98260-1-RR, Anti-Human EMR2/CD312 Rabbit Recombinant Antibody

Size: 100ug The EMR2/CD312 (98260-1-RR) by Proteintech is a Recombinant antibody targeting EMR2/CD312 in FC applications with reactivity to human samples 98260-1-RR targets EMR2/CD312 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: human PBMCs Recommended dilution Flow Cytometry (FC): FC : 0.13 ug per 10^6 cells in 100 μl suspension Background Information EMR2 (Epidermal Growth Factor-like module-containing Mucin-like Hormone Receptor 2), also known as CD312 or ADGRE2, is a member of the adhesion-GPCR family that contains extracellular EGF-like domains. EMR2 contains a total of five tandem EGF-like domains and expresses similar protein isoforms consisting of various numbers of EGF-like domains as a result of alternative RNA splicing (PMID: 10903844). EMR2 is restricted to myeloid cells including monocytes, macrophages, dendritic cells and granulocytes28 and its expression is highly regulated during monocyte/macrophage differentiation (PMID: 31969668).The ligation of EMR2 could increase neutrophil adhesion, migration and anti-microbial mediator production and could enhance the systemic inflammation (PMID: 27905560). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: egf-like module containing, mucin-like, hormone receptor-like 2 Calculated Molecular Weight: 90 kDa GenBank Accession Number: NM_013447.3 Gene Symbol: EMR2 Gene ID (NCBI): 30817 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: Q9UHX3-1 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.