Proteintech, 98282-1-RR, Anti-Human IL-1R1 Rabbit Recombinant Antibody

Size: 100ug The IL-1R1 (98282-1-RR) by Proteintech is a Recombinant antibody targeting IL-1R1 in FC applications with reactivity to human samples 98282-1-RR targets IL-1R1 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: HeLa cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information IL-1R1 (IL-1 receptor type 1, also known as p80, IL-1R-alpha or CD121a) is a 80 kDa transmembrane glycoprotein and a member of the interleukin-1 receptor family (PMID: 35163653; 29248002). It is a receptor for IL-1α, IL-1β, and interleukin-1 receptor antagonist (IL-1Ra). IL-1α and IL-1β interact with the extracellular domain of IL-1R1, triggering the recruitment of an accessory receptor, the IL-1RAcP, resulting in a functional receptor complex that initiates IL-1R1 signaling cascades (PMID: 35163653). IL-1Ra competes with active IL-1 and blocks binding to their common activating receptor IL-1R1 and, thus, inhibits IL-1 signaling (PMID: 35332327; 11641511). It has been reported that IL-1R1 may also bind IL-38 (PMID: 29248002). IL-1R1 expression has been found in many cell types including T cells, macrophages, neutrophils, eosinophils, basophils, mast cells, fibroblasts, and endothelial cells. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: interleukin 1 receptor, type I Calculated Molecular Weight: 65 kDa GenBank Accession Number: NM_000877.4 Gene Symbol: IL1R1 Gene ID (NCBI): 3554 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P14778 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.