Proteintech, 98354-3-RR, Anti-Mouse CD72 Rabbit Recombinant Antibody

Size: 100ug The CD72 (98354-3-RR) by Proteintech is a Recombinant antibody targeting CD72 in FC applications with reactivity to mouse samples 98354-3-RR targets CD72 in FC applications and shows reactivity with mouse samples. Tested Applications Positive FC detected in: mouse splenocytes Recommended dilution Flow Cytometry (FC): FC : 0.25 ul per 10^6 cells in 100 μl suspension Background Information CD72 is a type II transmembrane glycoprotein of 39-45 kDa and is expressed as a disulphide-linked homodimer (PMID: 1711157). CD72 is a pan B-cell marker covering the full range of differentiation from the very early stages of B cells to mature surface Ig+ B cells (PMID: 1384316). It is expressed in all stages of B cell development except plasma cells. CD72 is also expressed by dendritic cells, tissue macrophages in the red pulp of the spleen and von Kupffer cells in the liver (PMID: 8561576; 1384316). CD72 is the ligand for CD5 (PMID: 1711157). CD72 is a negative regulator of BCR signaling (PMID: 9590210). Interaction of CD100 with CD72 strictly tunes the strength of BCR signals and is essential for maintaining immunological homeostasis as well as generating a proper immune response (PMID: 16113236). Specification Tested Reactivity: mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: CD72 antigen Calculated Molecular Weight: 40 kDa GenBank Accession Number: NM_007654.2 Gene Symbol: Cd72 Gene ID (NCBI): 12517 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P21855 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.