Proteintech, 98377-1-RR, Anti-Human CD117/c-Kit Rabbit Recombinant Antibody

Size: 100ug The CD117/c-Kit (98377-1-RR) by Proteintech is a Recombinant antibody targeting CD117/c-Kit in FC applications with reactivity to human samples 98377-1-RR targets CD117/c-Kit in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: TF-1 cells, FC receptor blocked human blood cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information CD117, also known as c-Kit and SCFR, is a transmembrane protein with tyrosine kinase activity encoded by the oncogene c-kit (PMID: 2448137). It is a member of the type III receptor tyrosine kinase family, which also includes CSF-1R, PDGFRβ, PDGFRα, and FLT3 (PMID: 29518044). CD117 is expressed on hematopoietic stem cells and progenitor cells, mast cells, and is also found in a wide range of non-haemopoietic cell types (including melanocytes, germ cells, astrocytes, renal tubules, breast glandular epithelial cells, sweat glands, and interstitial cells of Cajal) (PMID: 10582338; 23073628). CD117 plays an important role in early hemopoiesis. It is also involved in pigmentation, fertility, gut movement, and some aspects of the nervous system (PMID: 23073628). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog Calculated Molecular Weight: 976 aa, 110 kDa GenBank Accession Number: BC071593 Gene Symbol: CD117 Gene ID (NCBI): 3815 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purfication UNIPROT ID: P10721 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.