Proteintech, 98383-2-RR, Anti-Human FGFR4 Rabbit Recombinant Antibody

Size: 100ug The FGFR4 (98383-2-RR) by Proteintech is a Recombinant antibody targeting FGFR4 in FC applications with reactivity to human samples 98383-2-RR targets FGFR4 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: HepG2 cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in 100 μl suspension Background Information Fibroblast growth factor receptor 4 (FGFR4) is a member of a highly conserved tyrosine kinase family, along with FGFR1-3. This family consists of an intracellular tyrosine kinase domain, a single transmembrane domain, and extracellular ligand binding domains (PMID:32492514). FGFR4 is the predominant FGFR isoform present in human hepatocytes. FGFR4 has been proposed to play a role in the observed induction of hepatocyte proliferation and carcinogenesis by FGF19; however, contradicting evidence proposing a protective role for FGFR4 in suppressing hepatoma progression has also been proposed(PMID:20018895). While the role of FGFR4 in cancer remains to be fully elucidated, several findings suggest that this receptor may be an important player in Hepatocellular carcinoma (HCC) development and/or progression (PMID:10336501). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Recombinant protein Predict reactive species Full Name: fibroblast growth factor receptor 4 Calculated Molecular Weight: 88 kDa GenBank Accession Number: BC011847 Gene Symbol: FGFR4 Gene ID (NCBI): 2264 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P22455 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.