Proteintech, 98592-3-RR, Anti-Human SCF Rabbit Recombinant Antibody

Size: 100ug The SCF (98592-3-RR) by Proteintech is a Recombinant antibody targeting SCF in FC (Intra) applications with reactivity to human samples 98592-3-RR targets SCF in FC (Intra) applications and shows reactivity with human samples. Tested Applications Positive FC (Intra) detected in: human bone marrow mesenchymal stromal cells Recommended dilution Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information Stem cell factor (SCF) is also named as mast cell growth factor (MGF), Kit ligand (Kitl), c-Kit ligand, steel factor and Kitlg. SCF is a pleiotropic cytokine (also as a dimeric molecule) that mediates regulatory effects on inflammation, tissue remodeling, and fibrosis through binding to and activating its receptor tyrosine kinase c-Kit (PMID: 1698553, PMID: 8630386, PMID: 23073628). SCF is the ligand of c-Kit, a member of the RTKs family. Molecular activity of RTKs is a primary stimulus of cell motility, and expression of the SCF/c-Kit axis is associated with cell migration (PMID: 28629522). SCF is a cytokine that synergizes the effects of Epo during erythropoiesis. Stem cell factor plays a well-described role in regulating the survival, proliferation, migration, and differentiation of hematopoietic progenitors, melanocytes, and germ cells (PMID: 36688460). More recent studies have demonstrated SCF expression in dermal and intestinal epithelial cells, and increased SCF expression has been reported in the inflamed mucosa of individuals with IBD and colonitis (PMID: 18200049, PMID: 30157426). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Product name: HumanKine® recombinant human SCF protein Source: -derived, Tag: Domain: of Sequence: Predict reactive species Full Name: KIT ligand Gene Symbol: SCF Gene ID (NCBI): 4254 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P21583 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.