Proteintech, 98655-2-RR, Anti-Mouse IL-31 Rabbit Recombinant Antibody

Size: 100ug The IL-31 (98655-2-RR) by Proteintech is a Recombinant antibody targeting IL-31 in FC (Intra) applications with reactivity to mouse samples 98655-2-RR targets IL-31 in FC (Intra) applications and shows reactivity with mouse samples. Tested Applications Positive FC (Intra) detected in: PMA, Ionomycin and Brefeldin A treated C57BL/6 Th2-polarized splenocytes Recommended dilution Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information IL-31 mRNA encodes a 164-aa precursor and a predicted 141-aa mature polypeptide, displaying an apparent molecular mass of 24 kDa in its glycosylated form. IL31 is a newly discovered four-helix bundle cytokine and expressed by several types of cells under both normal and disease state, such as activated CD4+T cells, mast cells, monocytes, macrophages, immature and mature monocyte-derived dendritic cells and so on. IL-31 signals through a heterodimeric receptor complex consisting of the IL31 receptor alpha (IL31Rα) and the oncostatin M receptor (OSMR). IL-31 plays a predominant function in the mediation of inflammatory and lymphoma-associated itch. Increased IL-31 expression has been detected in inflamed tissues from patients with atopic dermatitis, bowel diseases, allergic asthma and rhinitis. Specification Tested Reactivity: mouse Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg6811 Product name: Recombinant mouse IL-31 protein Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 24-163 aa of NM_029594.1 Sequence: TCSLSFGAPISKEDLRTTIDLLKQESQDLYNNYSIKQASGMSADESIQLPCFSLDREALTNISVIIAHLEKVKVLSENTVDTSWVIRWLTNISCFNPLNLNISVPGNTDESYDCKVFVLTVLKQFSNCMAELQAKDNTTC Predict reactive species Full Name: interleukin 31 Calculated Molecular Weight: 18 kDa GenBank Accession Number: NM_029594.1 Gene Symbol: Il31 Gene ID (NCBI): 76399 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q6EAL8 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.