Proteintech, 98678-1-RR, Anti-Human LY86 Rabbit Recombinant Antibody

Size: 100ug The LY86 (98678-1-RR) by Proteintech is a Recombinant antibody targeting LY86 in FC (Intra) applications with reactivity to human samples 98678-1-RR targets LY86 in FC (Intra) applications and shows reactivity with human samples. Tested Applications Positive FC (Intra) detected in: human PBMCs Recommended dilution Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information LY86, also known as protein MD-1, is a secreted glycoprotein that is associated with RP105 (TLR family proteins) and plays a significant role in the B cell surface expression of RP105. The RP105/MD-1 complex is expressed on immune cells, including B cells, macrophages, and dendritic cells (PMID: 37861500). By forming the RP105-MD-1 complex, LY86 fine-tunes recognition of bacterial lipopolysaccharide (LPS) and subsequent cytokine production, acting as both a facilitator and a brake on innate immune responses. LY86 influences sterile inflammatory conditions such as atherosclerosis, obesity, insulin resistance and cardiac remodeling, and is being explored as a biomarker for unstable carotid plaques and other immune-mediated diseases (PMID: 39085350). Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: CatNo: Eg3108 Product name: recombinant human LY86 protein Source: mammalian cells -derived, V37 Tag: C-rFc Domain: 21-162 aa of NM_004271.4 Sequence: GGGGKAWPTHVVCSDSGLEVLYQSCDPLQDFGFSVEKCSKQLKSNINIRFGIILREDIKELFLDLALMSQGSSVLNFSYPICEAALPKFSFCGRRKGEQIYYAGPVNNPEFTIPQGEYQVLLELYTEKRSTVACANATIMCS Predict reactive species Full Name: lymphocyte antigen 86 Calculated Molecular Weight: 18 kDa GenBank Accession Number: NM_004271.4 Gene Symbol: LY86 Gene ID (NCBI): 9450 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: O95711 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.