Proteintech, 98690-1-RR, Anti-Human TRPV4 Rabbit Recombinant Antibody

Size: 100ug The TRPV4 (98690-1-RR) by Proteintech is a Recombinant antibody targeting TRPV4 in FC applications with reactivity to human samples 98690-1-RR targets TRPV4 in FC applications and shows reactivity with human samples. Tested Applications Positive FC detected in: THP-1 cells Recommended dilution Flow Cytometry (FC): FC : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information TRPV4, also called VRL2 and VROAC, belongs to the transient receptor family and TrpV subfamily. It is a non-selective calcium permeant cation channel protein which involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. It is activated by low pH, citrate and phorbol esters. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Defects in TRPV4 are the cause of brachyolmia type 3 (BRAC3), spondylometaphyseal dysplasia Kozlowski type (SMDK) and metatropic dysplasia (MTD). Multiple transcript variants encoding different isoforms have been found. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: Peptide Predict reactive species Full Name: transient receptor potential cation channel, subfamily V, member 4 Calculated Molecular Weight: 98 kDa GenBank Accession Number: BC117426 Gene Symbol: TRPV4 Gene ID (NCBI): 59341 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: Q9HBA0 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.