Proteintech, 98749-1-RR, Anti-Human TGM2 Rabbit Recombinant Antibody

Size: 100ug The TGM2 (98749-1-RR) by Proteintech is a Recombinant antibody targeting TGM2 in FC (Intra) applications with reactivity to human samples 98749-1-RR targets TGM2 in FC (Intra) applications and shows reactivity with human samples. Tested Applications Positive FC (Intra) detected in: HeLa cells, HUVEC cells Recommended dilution Flow Cytometry (FC) (INTRA): FC (INTRA) : 0.25 ug per 10^6 cells in a 100 µl suspension Background Information Transglutaminase 2 (TGM2) is a ubiquitous and multifunctional calcium-dependent enzyme belonging to the transglutaminase family. It is best known for its canonical activity of catalyzing the cross-linking of proteins by forming stable ε-(γ-glutamyl)lysine isopeptide bonds, which contributes to extracellular matrix stabilization and wound healing. Beyond this, TGM2 exhibits GTPase activity, allowing it to function as a signaling G-protein in intracellular processes. It is implicated in a wide range of physiological functions, including cell adhesion, proliferation, and apoptosis, as well as pathological conditions such as celiac disease, fibrosis, neurodegenerative disorders, and cancer metastasis, where its dysregulated expression often contributes to disease progression. Specification Tested Reactivity: human Host / Isotype: Rabbit / IgG Class: Recombinant Type: Antibody Immunogen: unknow Predict reactive species Full Name: transglutaminase 2 (C polypeptide, protein-glutamine-gamma-glutamyltransferase) Gene Symbol: TGM2 Gene ID (NCBI): 7052 ENSEMBL Gene ID: ENSG00000198959 Conjugate: Unconjugated Form: Liquid Purification Method: Protein A purification UNIPROT ID: P21980 Storage Buffer: PBS with 0.09% sodium azide, pH 7.3. Storage Conditions: Store at 2 - 8°C. Stable for one year after shipment.