Proteintech, KE00251, Human CD40 ligand/CD154 ELISA Kit

Size: 96t / 5*96t / 10*96t Background Information The CD40 ligand (CD40L), also known as TRAP or CD154, is a member of the TNF superfamily of ligands. CD40L is primarily expressed on activated CD4+ T cells and on a small proportion of CD8+ T cells and platelets. It binds to CD40 on antigen-presenting cells (APC), which leads to many effects depending on the target cell type. It has been suggested that CD40/CD40L interactions regulate oxidative stress and affect various signaling pathways in both the immunological and the cardiovascular systems. The CD40/CD40L system is also involved in tumorigenesis. Its expression is tightly regulated, and abnormal levels of CD40L are associated with the pathogenesis of atheromatous plaque destabilization and thrombotic events. Multiple mutations in CD40LG gene have been identified that are associated with hyper-IgM immunodeficiency syndrome type 1. Apart from the 33 kDa transmembrane form, a soluble form of CD40L generated by ectodomain shedding has been reported. Specification Product name: Human CD40 ligand/CD154 ELISA Kit Tests: 1 X 96 well plate Sample type: Serum, Plasma Assay type: Sandwich Sensitivity: 4.2 pg/mL Range: 31.25-2000 pg/mL Reactivity: Human Tested applications: Sandwich ELISA Gene ID (NCBI): 959 Human plasma: 95% 1: 20 2: 20 3: 20 1: 24 2: 24 3: 24 Storage Instructions: All the reagents are stored at 2-8℃ for 6 months or -20℃ for 12 months. Refer to the protocol for further storage instructions. Synonyms: CD154, CD40 L, CD40 ligand, CD40L, CD40LG, gp39, hCD40L, HIGM1, IGM, IMD3, T BAM, T cell antigen Gp39, TNF related activation protein, TNFSF5, TRAP