Qiagen, 339501, Custom LNA mRNA Detection Probes (1 µmol synthesis)

1 µmol synthesis Custom LNA mRNA Detection Probes with option of different labels, provided in tube format

Features

- Sensitivity and specificity superior to DNA probes and riboprobes
- Short probes ideal for discriminating highly similar sequences such as splice variants and isoforms
- Online tools provide optimally designed LNA-enhanced probe in minutes
- Available with a wide selection of labels
- No cloning expertise required

Product Details

Custom design your own LNA-enhanced detection probes for any mRNA or lncRNA target in just minutes using our advanced online design tools. Custom LNA mRNA Detection Probes allow you to easily detect short RNAs and discriminate between highly similar RNAs. High affinity for their target sequences allows use of stringent hybridization and washing conditions, despite short probe lengths.

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Principle

- Optimization of probe length and the number and positions of LNA bases within the probe: ensures that the probes have the correct melting temperatures and avoids any potential self-hybridization.
- A detailed analysis of the probe's LNA pattern, based on our extensive knowledge of oligonucleotide design rules: ensures that LNA bases are not placed in positions where they could negatively affect the performance of the probe.
- Calculations of the target’s secondary structure: ensures that the probes only target accessible regions of the mRNA.
- BLAST searches: ensure that the probes will only target the relevant mRNA sequence.

Features

Product description

Probe design process