Qiagen, 626815, QuantiFERON SARS-CoV-2 Extended Pack

Extended Set (cat. no. 626215) plus Control Set (cat. no. 626015)Extended Set: Blood collection tubes coated with specific SARS-CoV-2 peptides pool from spike and additional peptides issued from the full genome of the SARS-CoV-2 virus; 100 Ag3 Tubes (2 x 50/rack)Control Set: Negative and positive control blood collection tubes; 100 Nil Tubes (2 x 50/rack); 100 Mitogen Tubes (2 x 50/rack)

Features

- Based on world-leading QuantiFERON IGRA technology
- Customizable solution to fit your research needs
- Unlock immune response potential for better research insights

Product Details

As T cells are becoming increasingly recognized for their role in SARS-CoV-2 infection and immunity, the exploration of immune response markers in COVID-19 infections is becoming the next tool for researching potential improvements in patient management and vaccination guidance (10–12).

QIAGEN is widely committed in the fight against COVID-19 and you can now count on the world-leading QuantiFERON IGRA technology to support your research toward fighting this pandemic.

The QuantiFERON SARS-CoV-2 Blood Collection Tubes and QuantiFERON ELISA are for Research Use Only and not for diagnostic use.

Performance

The QuantiFERON SARS-CoV-2 Blood Collection Tubes and QuantiFERON ELISA are for Research Use Only and not for diagnostic use. Performances have not been established yet.

Principle

You decide to work with what matters most for your research: the QuantiFERON SARS-CoV-2 RUO solution is composed of several components that can be ordered separately or combined to provide better research insights on patients’ immune status.

The QuantiFERON SARS-CoV-2 RUO solution is an original combination of blood collection tubes containing innovative specific peptides formulated to stimulate lymphocytes in heparinized whole blood involved in cell-mediated immunity. Plasma from the stimulated samples can then be used for detection of IFN-γ using a simple ELISA.

Procedure

The QuantiFERON Control Set Blood Collection Tubes (QFN Control BCTs) consist of the QuantiFERON Nil and QuantiFERON Mitogen BCTs. The QFN Control BCT workflow includes blood collection and processing to generate plasma for the detection of IFN-γ. QFN Nil and Mitogen BCTs are intended to be used as negative and positive controls in conjunction with other QuantiFERON Antigen Tubes, when workflow and donor controls are required.

The QuantiFERON SARS-CoV-2 Starter Set (QFN SARS-CoV-2) Blood Collection Tube is for Research Use Only and uses a combination of antigens specific to SARS-CoV-2 to stimulate lymphocytes in heparinized whole blood involved in cell-mediated immunity. Plasma from the stimulated samples can be used for detection of cytokines, including IFN-γ. Detection of IFN-γ can be measured using QuantiFERON ELISA. The QFN SARS-CoV-2 Blood Collection Tubes are not for use in diagnostic procedures.

The QuantiFERON Monitor Direct (QFM Direct) Blood Collection Tube uses a combination of antigens to stimulate lymphocytes in heparinized whole blood involved in cell-mediated immunity. Plasma from the stimulated samples can be used for detection of IFN-γ, which can be done using QuantiFERON ELISA. The QFM Direct BCT is for Research Use Only and not for diagnostic use.

The QuantiFERON ELISA (QFN ELISA) is a microplate coated with specific material for determining the concentration of IFN-γ in a human plasma sample (reported in International Units per ml; IU/ml). Analysis of results is performed using the QuantiFERON Software.

Applications

- Investigating infection severity in hospitalized COVID-19 patients
- Investigating patient prognosis in ICU
- Investigating cell-mediated immune (CMI) response following SARS-CoV-2 natural infection and/or COVID-19 vaccination

Numerous publications and recent research highlight the potential applications of immune response assays in COVID-19 infections, such as, but not limited to: