Abcam, ab101402, Anti-Sohlh2 antibody

Size: 50µL
Rabbit Polyclonal Sohlh2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SOHLH2 aa 1-200.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human SOHLH2 aa 1-200. The exact immunogen used to generate this antibody is proprietary information.Q9NX45

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.01% Thimerosal (merthiolate)Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Sohlh2 also known as Spermatogenesis and Oogenesis-specific basic Helix-Loop-Helix 2 is a transcription factor with a molecular mass of about 32 kDa. It is expressed in reproductive tissues notably in the ovaries and testes. Sohlh2 plays a mechanical role by binding to specific DNA sequences regulating the expression of genes essential for germ cell development. This protein influences the differentiation and function of cells critical for reproduction.
Biological function summary
Sohlh2 influences germline specification and is key for both oogenesis and spermatogenesis. By ensuring the proper expression of specific target genes it plays a pivotal role in reproductive organ development. Sohlh2 could form complexes with other transcription factors although further research may be needed to define such interactions comprehensively. The regulation and presence of Sohlh2 ensure that germ cells undergo proper development and maturation.
Pathways
Sohlh2 is integrated into reproductive pathways that regulate germ cell differentiation. It interacts through pathways involving gene expression and cellular differentiation. Proteins like Figla and Nobox also participate in these reproductive processes and together with Sohlh2 they orchestrate the development of gametes. These interactions are integral for maintaining fertility and proper reproductive system function.
Sohlh2 has implications in fertility issues and gonadal dysgenesis. Altered expression or mutations in Sohlh2 can contribute to conditions like premature ovarian failure or azoospermia. Disorders involving reproductive development may reflect dysregulation of related proteins such as Lhx8 which works alongside Sohlh2 in the same biological processes. Understanding these interactions and pathways is fundamental for potential therapeutic strategies in treating related fertility disorders.