Abcam, ab101465, Anti-MICU2 antibody

Size: 50µL
Rabbit Polyclonal MICU2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 46 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MICU2 aa 50-250.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human MICU2 aa 50-250. The exact immunogen used to generate this antibody is proprietary information.Q8IYU8

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
MICU2 also known as mitochondrial calcium uptake 2 is an important regulator of calcium ion influx into mitochondria. It is a 54 kDa protein that resides primarily in the inner mitochondrial membrane where it helps maintain calcium homeostasis. By modulating calcium uptake MICU2 influences various cellular processes and mitochondrial dynamics. Its expression levels vary among the tissues with notable levels observed in muscle and brain tissues.
Biological function summary
MICU2 is a component of the mitochondrial calcium uniporter complex which includes other proteins such as MCU and MICU1. This complex ensures proper calcium ion transfer across the mitochondrial membrane which is essential for ATP production maintenance of mitochondrial membrane potential and regulation of apoptotic signaling. MICU2 works as a gatekeeper preventing calcium overload and facilitating controlled entry of calcium ions.
Pathways
MICU2 is involved in pathways essential for cellular energy metabolism and apoptosis. It participates in the calcium signaling pathway where it functions alongside MCU to control calcium entry impacting processes like oxidative phosphorylation. Another related pathway is the intrinsic apoptotic pathway where MICU2’s regulation of calcium levels can influence mitochondrial-mediated apoptosis. In this context MICU1 acts as a supportive partner by providing threshold control for calcium uptake.
MICU2 is linked to neurodegenerative diseases and mitochondrial dysfunction disorders. Abnormalities in MICU2 expression or function can lead to improper calcium homeostasis contributing to conditions like Alzheimer's disease by affecting neuronal calcium signaling. The interaction of MICU2 with MCU and MICU1 within the uniporter complex is critical for maintaining cellular health and disruptions in these relationships may exacerbate disease progression.