Abcam, ab101940, Recombinant Human HDHD2 protein

Size: 100µg / 500µg
Recombinant Human HDHD2 protein is a Human Full Length protein, in the 1 to 259 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9H0R4,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
HDHD2 also known as haloacid dehalogenase-like hydrolase domain-containing protein 2 is an enzyme with a molecular weight of approximately 22 kDa. It primarily functions as a phosphatase which removes phosphate groups from specific substrates. HDHD2 is expressed in several tissues including the liver and brain. Its activity is integral to regulating phosphate metabolism and maintaining cellular homeostasis.
Biological function summary
HDHD2 hydrolyzes phosphoserines and plays an essential role in dephosphorylation processes. It is a component of protein complexes that control phosphorylation states within cells directly affecting protein functions. Through these actions HDHD2 influences cellular signaling and metabolism contributing to physiological processes such as enzyme regulation and substrate modification.
Pathways
HDHD2 participates in signaling pathways related to phosphate metabolism and energy balance. It is related to the energy production pathway and the regulation of cellular signaling cascades. This protein interacts with other enzymes like PPARG and PTPMT1 coordinating the maintenance of phosphate balance across cellular compartments.
Abnormalities in HDHD2 function can be linked to metabolic disorders including diabetes and obesity. Its disturbance affects phosphate homeostasis and potentially contributes to insulin resistance. HDHD2 interacts with proteins such as insulin receptors and SREBP-1c implicating it in metabolic dysregulation associated with these conditions.