Abcam, ab102010, Anti-ERM / Etv5 antibody

Size: 100µL
Rabbit Polyclonal ERM / Etv5 antibody. Suitable for ICC/IF, WB and reacts with Human, Recombinant fragment samples. Cited in 33 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ETV5 aa 200-450.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Fragment Protein within Human ETV5 aa 200-450. The exact immunogen used to generate this antibody is proprietary information.P41161

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7Preservative: 0.025% Proclin 300Constituents: PBS, 20% Glycerol (glycerin, glycerine), Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The ERM (Etv5) protein also known as ERM products or ERM Boston in some contexts functions as a transcription factor within the ETS family of proteins. This protein has a molecular weight of approximately 57 kDa. Expressed in a variety of tissues including the brain and reproductive organs Etv5 plays an important role in regulating gene expression by binding to specific DNA sequences. Its activities involve promoting transcription of genes vital for development and cellular differentiation.
Biological function summary
The ERM (Etv5) protein influences numerous developmental processes and cellular states. It participates in the MAP kinase signaling cascade where it facilitates responses to growth factors. By serving as a component in several regulatory complexes Etv5 modulates the expression of genes that control cell proliferation and survival. This activity is important for tissue development and maintenance especially in stem and progenitor cells.
Pathways
The ERM (Etv5) protein interacts with MAPK and PI3K/AKT signaling pathways essential for cellular growth and survival. These pathways often connect to the regulation of cell cycle and apoptosis involving proteins like Bcl-2 and c-Jun. Etv5 helps mediate the cellular response to external stimuli via these pathways influencing both proliferation and differentiation.
Irregular expression of the ERM (Etv5) protein correlates with conditions such as cancer and infertility. Overexpression or mutations in Etv5 have been linked to various cancers including prostate cancer where its interaction with proteins like PTEN influences tumor growth and progression. In reproductive disorders Etv5 plays a role in testicular germ cell development with disruptions potentially leading to infertility.