Abcam, ab102026, Recombinant Human Mob1A protein

Size: 100µg
Recombinant Human Mob1A protein is a Human Full Length protein, in the 1 to 216 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9H8S9,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 30% Glycerol (glycerin, glycerine), 1.16% Sodium chloride, 0.316% Tris HCl, 0.077% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
This product was previously labelled as MOBK1B

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Mob1A also known as Mps One Binder kinase activator-like 1A is a protein involved in cell signaling pathways. It has a molecular mass of approximately 25 kDa. Mob1A is found in various tissues but it shows elevated expression levels in the liver kidney and lung. Its structural attributes contribute to interacting with other cellular proteins assisting in regulation of cell cycle progression.
Biological function summary
Mob1A acts as a core component of the Hippo signaling pathway playing an important role in cell proliferation and apoptosis regulation. It forms a complex with large tumor suppressor kinase 1 (LATS1) and facilitates interaction with other pathway components. The interaction with LATS1 enhances the phosphorylation activity which then has further consequences for cellular processes. This function is critical for preventing uncontrolled cell growth and ensuring proper organ size is maintained.
Pathways
Mob1A participates in the Hippo and Wnt signaling pathways. Within the Hippo pathway Mob1A works closely with proteins such as YAP/TAZ which are regulatory proteins important for gene expression control. In the Wnt pathway Mob1A contributes indirectly to cell fate determination. These connections highlight its importance in managing cellular growth and differentiation requiring careful orchestration of its interactions.
Mob1A shows significant involvement in cancer and liver diseases. Dysregulation within the Hippo pathway where Mob1A plays an important role often leads to tumorigenesis due to increased cellular proliferation. Research shows correlations between altered Mob1A function and hepatocellular carcinoma where Mob1A interacts with other proteins like MST1/2 to influence disease progression. Understanding these interactions may offer therapeutic insights for managing such conditions.