Abcam, ab103302, Recombinant Human AIF1L protein

Size: 100µg / 500µg
Recombinant Human AIF1L protein is a Human Full Length protein, in the 1 to 150 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q9BQI0,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 20% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
AIF1L also known as Allograft Inflammatory Factor 1-like is a protein with a molecular weight of approximately 17 kDa. It's mainly expressed in activated macrophages and microglia. AIF1L is also detected in several other tissues such as the spleen pancreas and small intestine. In cells it localizes to the cytoplasm and sometimes the nucleus contributing to cytoskeletal organization.
Biological function summary
The protein functions in immune response modulation and cellular activation processes. It does not form part of a known protein complex but it contributes significantly to actin cytoskeleton rearrangement suggesting a role in cell migration and phagocytosis. AIF1L influences inflammatory responses by modulating macrophage activity which is important for tissue injury response and repair processes.
Pathways
AIF1L interacts with cytoskeletal signaling pathways and immune system pathways. AIF1L's role in actin rearrangement links it to pathways involved in cellular motility and structural integrity. Its modulation of inflammation connects it to pathway interactions with other proteins like actin-binding proteins and cytokines influencing immune system regulation and macrophage activation.
AIF1L holds relevance to autoimmunity and atherosclerosis where immune response regulation is disrupted. In autoimmune conditions the dysregulation of pathways involving AIF1L can exacerbate immune cell activation and inflammation. In atherosclerosis its function in macrophage activation intersects with proteins like CD68 contributing to foam cell formation and plaque buildup in arterial walls advancing our understanding of inflammatory processes in cardiovascular diseases.