Abcam, ab103547, Anti-CYP2C8 antibody

Size: 100µg
Rabbit Polyclonal CYP2C8 antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Cytochrome P450 2C8.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:Yes,
Reacts with:Human,
Applications:WBSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Recombinant Full Length Protein corresponding to Human Cytochrome P450 2C8.P10632

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Protein A, Storage buffer-pH: 7.4Constituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
CYP2C8 also known as Cytochrome P450 2C8 is a member of the cytochrome P450 superfamily of enzymes. It has a molecular mass of approximately 56 kDa. CYP2C8 localizes mainly in the liver but can be found in smaller amounts in other tissues such as the kidney and heart. This enzyme plays a role in oxidizing various substances impacting drug metabolism. The enzyme achieves this by catalyzing reactions involved in drug detoxification and steroid synthesis.
Biological function summary
CYP2C8 facilitates the metabolism of xenobiotics and endogenous compounds contributing to homeostasis. It forms part of the cytochrome P450 hepatic microsomal enzyme complex which contains multiple enzymes responsible for oxidative metabolism. CYP2C8 metabolizes several clinically important drugs including paclitaxel and amodiaquine as well as endogenous arachidonic acid impacting vascular biology.
Pathways
This enzyme acts within the drug metabolism and arachidonic acid metabolism pathways. Within these pathways it works closely with other cytochrome P450 enzymes such as CYP3A4. The drug metabolism pathway requires CYP2C8 for phase I of drug processing which modifies drugs into more water-soluble compounds. In arachidonic acid metabolism CYP2C8 is important to forming bioactive epoxyeicosatrienoic acids that function as signaling molecules in tissues.
Dysregulation of CYP2C8 activity relates to conditions such as drug-induced liver injury and cardiovascular diseases. Variants in the CYP2C8 gene can lead to altered enzyme activity influencing drug response and toxicity. Furthermore its interaction with CYP2C9 in pharmacogenomic variability can affect patients' susceptibility to adverse drug reactions emphasizing the role in personalized medicine approaches.