Abcam, ab103901, Recombinant Human NCALD protein

Size: 100µg
Recombinant Human NCALD protein is a Human Full Length protein, in the 1 to 193 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P61601,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 40% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage duration-1-2 weeks, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
NCALD also known as Neurocalcin Delta is a calcium-binding protein that belongs to the neuronal calcium sensor (NCS) family. With a molecular mass of approximately 23 kDa it serves key roles in calcium signaling. The protein has wide expression being found mainly in the brain but it is also present in other tissues such as the retina and olfactory bulb. Its presence in these areas suggests an important role in neuronal functions.
Biological function summary
Neurocalcin Delta modulates signal transduction by affecting the activity of calcium-dependent enzymes and ion channels. It does so by binding calcium ions which causes a conformational change allowing it to interact with its target proteins. While NCALD does not typically form large protein complexes it often interacts with smaller complexes influencing their function. Its regulatory impact on enzymes and ion channels highlights its important role in maintaining cellular functions.
Pathways
NCALD contributes to various neural signaling pathways notably the calcium signaling pathway and the phototransduction pathway. Within the calcium signaling pathway NCALD interacts with proteins such as calmodulin and recoverin which are important for transmitting calcium signals that control numerous cellular processes. In the phototransduction pathway NCALD functions alongside proteins involved in converting light signals into neuronal signals in the retina.
NCALD links to conditions like Alzheimer's disease and diabetic retinopathy. In Alzheimer's disease disruptions in calcium signaling pathways with NCALD as a part can lead to neurodegeneration. Additionally in diabetic retinopathy changes in NCALD expression can harm retinal neural activity. It connects to other proteins such as synaptotagmin and calpain which play parts in these diseases. Understanding NCALD's role in such conditions could offer potential therapeutic targets.