Abcam, ab104481, Recombinant Human SNRPD2 protein

Size: 100µg / 500µg
Recombinant Human SNRPD2 protein is a Human Full Length protein, in the 1 to 118 aa range, expressed in Escherichia coli, with >90%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>90% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:SDS-PAGE, Mass SpecSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:P62316,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 50% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0154% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Product details:
Previously labelled as SNRPD2.
This product was previously labelled as Sm-D2

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The small nuclear ribonucleoprotein D2 (SNRPD2) also known as Sm-D2 is a component of the spliceosomal small nuclear ribonucleoproteins (snRNP) essential for pre-mRNA splicing. It has a molecular weight of approximately 14 kDa and is ubiquitously expressed in various tissues highlighting its significant function across different cell types. SNRPD2 is part of the Sm protein family which plays an important role in the assembly and function of spliceosomal snRNPs.
Biological function summary
SNRPD2 participates in the formation of the spliceosomal core necessary for the removal of introns from pre-mRNA which is important for generating mature mRNA transcripts. This protein is a part of the spliceosome complex consisting of other snRNPs and numerous accessory proteins. SNRPD2's involvement in mRNA processing highlights its fundamental role in gene expression regulation affecting how cells translate genetic information into functional proteins.
Pathways
SNRPD2 is a critical element in the spliceosome pathway a major route for the post-transcriptional modification of RNA. This pathway is integral to the regulation of alternative splicing events influencing protein diversity. SNRPD2 also interacts with other spliceosomal proteins such as SNRPB and SNRPE cooperating to facilitate precise exon-exon junctions. The fidelity of this pathway depends substantially on the integrity and functionality of SNRPD2 alongside its protein partners.
SNRPD2 shows a connection to autoimmune conditions such as systemic lupus erythematosus (SLE) where autoantibodies target snRNP components including SNRPD2. This autoimmune disorder may disrupt normal spliceosomal function contributing to disease pathology. Additionally alterations in splicing pathways involving SNRPD2 have links to certain cancers where dysregulated splicing can lead to oncogenic transformations. Understanding SNRPD2's role in these conditions may reveal therapeutic targets for modulating splicing in disease contexts.