Abcam, ab105131, Recombinant Human calcyphosine protein

Size: 100µg
Recombinant Human calcyphosine protein is a Human Full Length protein, in the 1 to 189 aa range, expressed in Escherichia coli, with >95%, suitable for SDS-PAGE, Mass Spec.
Key facts
Purity:>95% SDS-PAGE,
Expression system:Escherichia coli,
Tags:His tag N-Terminus,
Applications:Mass Spec, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:No,
Accession:Q13938,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 8Constituents: 10% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.0308% (R*,R*)-1,4-Dimercaptobutan-2,3-diol

Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Calcyphosine also known as CAPS is a calcium-binding protein with a molecular mass of approximately 22 kDa. It plays a role in intracellular calcium signaling. Calcyphosine expression occurs widely in multiple tissues with high levels observed in the thyroid gland and epithelial tissues. It binds calcium ions impacting cellular processes such as signal transduction and cell communication.
Biological function summary
Calcyphosine influences several cellular functions related to calcium homeostasis and signaling. It does not form part of any larger complex but modulates cellular activities by regulating calcium ion concentrations inside cells. This regulation is critical for functions like muscle contraction hormone secretion and neurotransmitter release. Its presence in different tissues suggests diverse roles depending on the cellular environment.
Pathways
Calcyphosine plays a role in calcium-dependent pathways significant for maintaining cellular activities. It intersects with the calcium signaling pathway affecting proteins like calmodulin and calcineurin which further mediate various cellular responses. These interactions alter signal transmission processes vital for cell responses and adaptations.
Studies have noted calcyphosine's involvement in thyroid-related conditions and some cancers. Altered expression levels link the protein to thyroid disorders potentially affecting thyroid hormone production and regulation. Calcyphosine's interaction with proteins like TSH receptor and thyroid transcription factors highlights its role in thyroid function and its potential influence on thyroid pathology and neoplastic conditions.