Abcam, ab105330, Anti-TRIM71/LIN41 antibody

Size: 100µg
Rabbit Polyclonal TRIM71/LIN41 antibody. Suitable for ICC, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human TRIM71.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:WB, ICCSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human TRIM71. The exact immunogen used to generate this antibody is proprietary information.Q2Q1W2

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The TRIM71 protein also known as LIN41 is a E3 ubiquitin ligase with a molecular weight of approximately 110 kDa. It regulates protein levels by tagging specific substrates with ubiquitin for proteasomal degradation. TRIM71 is expressed in various tissues including embryonic stem cells and the central nervous system. It functions in the regulation of developmental pathways serving a role in controlling cell differentiation and proliferation.
Biological function summary
TRIM71 plays an important role in the regulation of gene expression and cellular processes. This protein interacts as part of ribonucleoprotein complexes which influence RNA stability and translation. It is involved in the repression of target mRNAs through binding and modifying RNA-binding proteins which in turn affects gene expression during early development. TRIM71 also contributes to maintaining the balance between stem cell self-renewal and differentiation ensuring proper organismal development.
Pathways
TRIM71 actively participates in mTOR and Wnt signaling pathways. Within the mTOR pathway TRIM71 influences cell growth and metabolism by modulating protein synthesis and degradation. In the Wnt signaling pathway it regulates cell fate decisions and is linked with proteins such as β-catenin and Axin which are important for proper signal transduction. Through these pathways TRIM71 integrates signal inputs to control cellular behavior and development.
TRIM71 shows significant connections to cancer and neurodevelopmental disorders. In cancer abnormal expression or mutations of TRIM71 lead to uncontrolled cell growth due to its role in developmental pathways. It closely interacts with proteins like MYC which are critical in tumorigenesis. In neurodevelopmental disorders disruptions in TRIM71 function can impair neural cell differentiation and proliferation contributing to disorders such as microcephaly. Its interactions with other developmental regulators further highlight its impact on neurological health.