Abcam, ab105416, Anti-SLC39A1 antibody

Size: 100µg
Rabbit Polyclonal SLC39A1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human SLC39A1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Mouse, Human,
Applications:ICC/IF, WB, IHC-PSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human SLC39A1. The exact immunogen used to generate this antibody is proprietary information.Q9NY26,
Specificity:At least two isoforms of SLC39A1 are known to exist; this antibody will recognize both isoforms. SLC39A1 antibody is predicted to not cross-react with other SLC39A1 family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
SLC39A1 also known as ZIP1 is a zinc transporter protein that facilitates the influx of zinc ions into cells. This protein consists of 324 amino acids resulting in a molecular mass of approximately 34.26 kDa. SLC39A1 is expressed in various tissues throughout the body with high levels observed in the prostate pancreas and other zinc-related tissues. The protein belongs to the ZIP family of metal ion transporters which is key in maintaining intracellular zinc homeostasis.
Biological function summary
The SLC39A1 protein plays an essential role in cellular zinc uptake by increasing cytoplasmic zinc concentrations. This protein is not part of a larger complex but interacts with zinc ions directly ensuring adequate zinc availability for numerous cellular processes. Zinc is a critical cofactor for many enzymes and is necessary for proper immune function protein synthesis and cellular proliferation. By regulating zinc levels in cells SLC39A1 supports diverse physiological functions and maintains cellular health.
Pathways
SLC39A1 participates in zinc homeostasis and signal transduction pathways. It is pivotal in the regulation of the metallothionein expression pathway which helps detoxify heavy metals and protect against oxidative stress. Also SLC39A1 interacts with the NF-κB signaling pathway where zinc acts as a second messenger influencing cell survival and immune response. Proteins such as MT (metallothionein) and IκBα interact with SLC39A1 in these pathways thereby linking zinc transport to broader cellular functions and responses.
Disruptions in SLC39A1 function have been linked to prostate cancer and neurodegenerative diseases. In prostate cancer altered zinc transport by SLC39A1 is associated with reduced cellular zinc levels contributing to tumorigenesis. The reduction in zinc affects various proteins involved in prostate cancer progression including the androgen receptor. In neurodegenerative diseases like Alzheimer's dysfunctional zinc homeostasis related to abnormal SLC39A1 activity leads to increased oxidative stress and contributes to neuronal damage. Understanding the role of SLC39A1 in these conditions is important for developing targeted therapeutic strategies.