Abcam, ab105419, Anti-LMBRD1 antibody

Size: 100µg
Rabbit Polyclonal LMBRD1 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human LMBRD1.
Key facts
Host species:Rabbit,
Clonality:Polyclonal,
Isotype:IgG,
Carrier free:No,
Reacts with:Human,
Applications:IHC-P, WB, ICC/IFSee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Immunogen:Synthetic Peptide within Human LMBRD1. The exact immunogen used to generate this antibody is proprietary information.Q9NUN5,
Specificity:LMBRD1 antibody is predicted to not cross-react with other LMBRD1 family members.

Properties and Storage Information:
Form-Liquid, Purification technique-Affinity purification Immunogen, Storage buffer-pH: 7.2Preservative: 0.02% Sodium azideConstituents: PBS, Shipped at conditions-Blue Ice, Appropriate short-term storage conditions-+4°C, Appropriate long-term storage conditions-+4°C

Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
LMBRD1 also known as LMBR1 domain containing 1 functions as an essential protein involved in the transport of cobalamin (vitamin B12) across lysosomal membranes. This protein has a molecular mass of approximately 68 kDa. Expression of LMBRD1 occurs in various tissues including the liver and kidney where vitamin B12 metabolism is particularly active.
Biological function summary
LMBRD1 mediates intracellular distribution of vitamin B12 which is vital for proper metabolic functions. It forms part of a complex system with other proteins such as MMACHC and CBLIF that are responsible for cobalamin processing and transport. These interactions highlight the protein’s critical role in maintaining vitamin B12 homeostasis at the cellular level.
Pathways
LMBRD1 participates in metabolic pathways relating to vitamin B12 bioavailability and utilization. It plays a role in the cobalamin metabolic pathway ensuring the conversion of cobalamin into its active forms methylcobalamin and adenosylcobalamin. The interaction with proteins such as MMACHC and CBLF within these pathways illustrates its importance in nutrient metabolism and cellular proliferation processes.
LMBRD1 mutations can cause a condition known as methylmalonic aciduria and homocystinuria which stem from cobalamin processing dysfunction. This protein's role in B12 metabolism makes it relevant for understanding these metabolic disorders. Moreover LMBRD1 interacts with proteins like AMN which are involved in B vitamin absorption processes further connecting it to conditions related to nutrient deficiencies.